초록접수 현황
| 17F-158 | 구연 미채택시 포럼 발표 |
Survival and Postoperative Outcomes after Lung Transplantation in Connective Tissue Related Interstitial Lung Disease.
Jee Won Suh¹, Jin Gu Lee¹, Kyoung Sik Narm¹, Sujin Jung², Moo Suk Park³, Song Yee Kim³, Joo Han Song³, Hyo Chae Paik¹
¹Department of Thoracic and Cardiovascular Surgery, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea., ²Department of Internal Medicine-Infection, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea., ³Department of Internal Medicine-Pulomary, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea
Purpose : Lung involvement is one of the most common and clinically important manifestations of connective tissue disease (CTD). Lung transplantation for these patients was controversial, but it can be considered if there is no response to sufficient immunosuppressive agents. The aim of this study is to known difference between IPF and CTD-ILD patients and compared immediate postoperative outcome, rejection and overall survival in patients with CTD-ILD and idiopathic pulmonary fibrosis (IPF).
Methods : From January 1, 2010 to June 30, 2017, patients who underwent lung transplantation with IPF or CTD-ILD were enrolled. A total of 124 patients were enrolled during this period, 102 (82.3%) were IPF patients and 22 (17.7%) were CTD-ILD patients. Analystic data included baseline characteristics, postoperative outcomes, rejection and overall survival.
Results : Mean age was 57.42±8.70 yr in IPF patients and 50.18±11.08 (p=0.008). Recipient smoking history and donor smoking history were higher in IPF patients (60.8% vs 27.3%, p=0.005, 56.9% vs 22.7%, p=0.005). Rate of PRA >15% before transplant was higher in CTD-ILD patients (31 (33.0%) vs 14 (63.6%), p=0.014). Rate of wean from ECMO at OR was higher in IPF patients (52 (64.2%) vs 8 (38.1%), p=0.045) in univariate analysis. 3 year survival was not significantly different among two groups (50.9% in IPF and 53.3% in CTD-ILD, p=0.205).
Conclusion : We found no significant differences in 3 year survival, rejection and early postoperative outcome in patients who underwent lung transplantation for CTD-ILD compared with IPF. In selected candidates, CTD-ILD patients should be considered to indication for lung transplantation.
Methods : From January 1, 2010 to June 30, 2017, patients who underwent lung transplantation with IPF or CTD-ILD were enrolled. A total of 124 patients were enrolled during this period, 102 (82.3%) were IPF patients and 22 (17.7%) were CTD-ILD patients. Analystic data included baseline characteristics, postoperative outcomes, rejection and overall survival.
Results : Mean age was 57.42±8.70 yr in IPF patients and 50.18±11.08 (p=0.008). Recipient smoking history and donor smoking history were higher in IPF patients (60.8% vs 27.3%, p=0.005, 56.9% vs 22.7%, p=0.005). Rate of PRA >15% before transplant was higher in CTD-ILD patients (31 (33.0%) vs 14 (63.6%), p=0.014). Rate of wean from ECMO at OR was higher in IPF patients (52 (64.2%) vs 8 (38.1%), p=0.045) in univariate analysis. 3 year survival was not significantly different among two groups (50.9% in IPF and 53.3% in CTD-ILD, p=0.205).
Conclusion : We found no significant differences in 3 year survival, rejection and early postoperative outcome in patients who underwent lung transplantation for CTD-ILD compared with IPF. In selected candidates, CTD-ILD patients should be considered to indication for lung transplantation.
책임저자: Hyo Chae Paik
Department of Thoracic and Cardiovascular Surgery, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea
발표자: Jee Won Suh, E-mail : suh_1225@yuhs.ac