초록접수 현황
| 17F-183 | 구연 미채택시 포럼 발표 |
The Association Between Cigarette Smoking and Histologic Subtypes in Resected Lung Adenocarcinoma
Jung Hoon Yi, Pil Jo Choi, Sang Seok Jeong, Joo Hyun Cho
Department of Thoracic and Cardiovascular Surgery, Dong-A University Hospital, Dong-A University College of Medicine, Busan, Republic of Korea
Purpose : Smokers have shown an unfavorable outcome when compared with never smokers in lung adenocarcinoma. However, it is unclear how smoking affects prognosis. We investigated the prognostic factor of survival and recurrence, and association between smoking and the factor.
Methods : A total of 233 consecutive patients with pathologic T1-4N0-2M0 lung adenocarcinoma who underwent complete resection with systematic lymph node dissection from January 2004 to July 2015 were studied retrospectively. Predominant histologic subtypes were divided into three subgroups (lepidic [LEP], acinar or papillary [ACN/PAP], solid or micropapillary [SOL/MIP]) depending on the reported impact on the prognosis.
Results : Univariate and multivariate Cox proportional hazard analyses revealed ‘predominant subtype group’ was an independent poor prognostic factor. When compared with LEP group, SOL/MIP group had poorer prognosis in overall survival (hazard ratio [HR] 3.107; p=0.022) and recurrence (HR 2.754; p=0.018). SOL/MIP group was associated significantly with ever smoker, larger tumor size, and presence of nodal metastasis and visceral pleural invasion. In the results of univariate and multivariate logistic regression analyses, smoking status (HR 2.908; p=0.005) and tumor size larger than 3cm (HR 2.296; p=0.025) were independent predictive factors of SOL/MIP subtype. Smoking quantity (pack-year) was significantly greater in SOL/MIP group (35.0 ± 18.1) than in LEP group (16.2 ± 8.6) (p=0.000). There was no difference in smoking quantity between predominant SOL/MIP group (35.0 ± 18.1) and non-predominant SOL/MIP group (29.2 ± 13.8) (p=0.150).
Conclusion : A larger smoking quantity is related to SOL/MIP subtype, which results in poorer outcomes on survival and recurrence.
Methods : A total of 233 consecutive patients with pathologic T1-4N0-2M0 lung adenocarcinoma who underwent complete resection with systematic lymph node dissection from January 2004 to July 2015 were studied retrospectively. Predominant histologic subtypes were divided into three subgroups (lepidic [LEP], acinar or papillary [ACN/PAP], solid or micropapillary [SOL/MIP]) depending on the reported impact on the prognosis.
Results : Univariate and multivariate Cox proportional hazard analyses revealed ‘predominant subtype group’ was an independent poor prognostic factor. When compared with LEP group, SOL/MIP group had poorer prognosis in overall survival (hazard ratio [HR] 3.107; p=0.022) and recurrence (HR 2.754; p=0.018). SOL/MIP group was associated significantly with ever smoker, larger tumor size, and presence of nodal metastasis and visceral pleural invasion. In the results of univariate and multivariate logistic regression analyses, smoking status (HR 2.908; p=0.005) and tumor size larger than 3cm (HR 2.296; p=0.025) were independent predictive factors of SOL/MIP subtype. Smoking quantity (pack-year) was significantly greater in SOL/MIP group (35.0 ± 18.1) than in LEP group (16.2 ± 8.6) (p=0.000). There was no difference in smoking quantity between predominant SOL/MIP group (35.0 ± 18.1) and non-predominant SOL/MIP group (29.2 ± 13.8) (p=0.150).
Conclusion : A larger smoking quantity is related to SOL/MIP subtype, which results in poorer outcomes on survival and recurrence.
책임저자: Pil Jo Choi
Department of Thoracic and Cardiovascular Surgery, Dong-A University Hospital, Dong-A University College of Medicine, Busan, Republic of Korea
발표자: Jung Hoon Yi, E-mail : yjh051@daum.net