초록접수 현황
| 17F-188 | 구연 발표 |
Resection Margin Distance of Resected Lepidic-dominant Lung Cancer does Not Affect Recurrence after Sublobar Resection
Youngkyu Moon, Jae Kil Park, Kyo Young Lee, Sook Whan Sung, Seok Whan Moon, Seha Ahn
Department of Thoracic and Cardiovascular Surgery, Seoul St. Mary’s Hospital, The Catholic University College of Medicine, Seoul, Republic of Korea
Purpose : A sufficient resection margin is required for the sublobar resection of lung cancers. However, the distance of the resection margin may not be important in lepidic-dominant adenocarcinoma, because such tumors are non- or less invasive. The purpose of this study was to determine the effect of resection margin distance on the outcome of patients with lepidic-dominant lung cancer after sublobar resection.
Methods : This study included 133 patients with small (≤2 cm), clinical N0M0 lung cancer who underwent sublobar resection with curative intent. The patients were divided into 4 groups: Group A, lepidic-dominant tumor with margin/tumor ratio <1; Group B, lepidic-dominant tumor with margin/tumor ratio ≥1; Group C, non-lepidic tumor with margin/tumor ratio <1; Group D, non-lepidic tumor with margin/tumor ratio ≥1. The clinicopathological features and survival outcomes between Group A and B patients, and between Group C and D patients were compared.
Results : The 5-year recurrence-free survival (RFS) rates of Group A and B patients were both 100%. The 5-year RFS rates of Group C and D patients were 49.9% and 97.1%, respectively (p=0.009). By multivariate analysis, the margin/tumor ratio was a significant independent factor for recurrence in patients with nonlepidic tumors (hazard ratio = 0.157, 95% confidence interval 0.027-0.898; p=0.037).
Conclusion : Tumor recurrence after sublobar resection is not associated with short resection margins in patients with lepidic dominant lung cancer. However, a short resection margin is a significant risk factor for recurrence in patients with non-lepidic tumors.
Methods : This study included 133 patients with small (≤2 cm), clinical N0M0 lung cancer who underwent sublobar resection with curative intent. The patients were divided into 4 groups: Group A, lepidic-dominant tumor with margin/tumor ratio <1; Group B, lepidic-dominant tumor with margin/tumor ratio ≥1; Group C, non-lepidic tumor with margin/tumor ratio <1; Group D, non-lepidic tumor with margin/tumor ratio ≥1. The clinicopathological features and survival outcomes between Group A and B patients, and between Group C and D patients were compared.
Results : The 5-year recurrence-free survival (RFS) rates of Group A and B patients were both 100%. The 5-year RFS rates of Group C and D patients were 49.9% and 97.1%, respectively (p=0.009). By multivariate analysis, the margin/tumor ratio was a significant independent factor for recurrence in patients with nonlepidic tumors (hazard ratio = 0.157, 95% confidence interval 0.027-0.898; p=0.037).
Conclusion : Tumor recurrence after sublobar resection is not associated with short resection margins in patients with lepidic dominant lung cancer. However, a short resection margin is a significant risk factor for recurrence in patients with non-lepidic tumors.
책임저자: Youngkyu Moon
Department of Thoracic and Cardiovascular Surgery, Seoul St. Mary’s Hospital, The Catholic University College of Medicine, Seoul, Republic of Korea
발표자: Youngkyu Moon, E-mail : mykae@catholic.ac.kr