초록접수 현황
| 17F-191 | 구연 미채택시 포럼 발표 |
Analysis of Impact of Interstitial Lung Disease on Patient who Underwent Pulmonary Resection for Lung Cancer
Kyoung Shik Narm, Jee Won Suh, Seong Yong Park, Dae Joon Kim, Kyung Young Chung, Jin Gu Lee
Department of Thoracic and Cardiovascular Surgery, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea
Purpose : We investigated the outcome of patients with interstitial lung disease (ILD) and lung cancer after surgical resection, along with risk factors of survival and acute exacerbation.
Methods : Between 2002 and 2016, total 74 patients with ILD received surgical resection for lung cancer. The demographics, operative and survival data were reviewed
Results : Mean age was 72±8 years old. 51 (68.9%) patients received video-assisted thoracic surgery (VATS). Lobectomy and sublobar resection were performed to 58 (78.4%) and 15 (20.3%) patients, respectively. 32 (43.2%) patients experienced acute exacerbation during early postoperative period. 30-, 90- days mortality and 5-year survival rate were significantly worse than patients without ILD in the same study period (8.1%, 21%, and 21.2% vs. 1.3%, 3.1%, and 73.8%, respectively, p<0.001). The leading cause of death was respiratory failure (57.8%), followed by cancer-related death (35.6%). Among 25 patients who received adjuvant therapy, 10 patients died of respiratory failure during or shortly after adjuvant therapy. Old age (HR 1.07, p=0.011), stage III (HR 4.11, p=0.003) and acute exacerbation (HR 3.14, p=0.004) were significant risk factors for survival. Open thoracotomy (OR 3.06, p=0.083) was risk factor for acute exacerbation. Sublobar resection showed similar survival rate and lower rate of acute exacerbation than lobectomy, although statistically not significant (26.7% vs. 46.6%, p=0.165)
Conclusion : ILD increased the risk of pulmonary resection for lung cancer. VATS were preventive for acute exacerbation. Adjuvant therapy should be considered after careful weighing of risk and benefit.
Methods : Between 2002 and 2016, total 74 patients with ILD received surgical resection for lung cancer. The demographics, operative and survival data were reviewed
Results : Mean age was 72±8 years old. 51 (68.9%) patients received video-assisted thoracic surgery (VATS). Lobectomy and sublobar resection were performed to 58 (78.4%) and 15 (20.3%) patients, respectively. 32 (43.2%) patients experienced acute exacerbation during early postoperative period. 30-, 90- days mortality and 5-year survival rate were significantly worse than patients without ILD in the same study period (8.1%, 21%, and 21.2% vs. 1.3%, 3.1%, and 73.8%, respectively, p<0.001). The leading cause of death was respiratory failure (57.8%), followed by cancer-related death (35.6%). Among 25 patients who received adjuvant therapy, 10 patients died of respiratory failure during or shortly after adjuvant therapy. Old age (HR 1.07, p=0.011), stage III (HR 4.11, p=0.003) and acute exacerbation (HR 3.14, p=0.004) were significant risk factors for survival. Open thoracotomy (OR 3.06, p=0.083) was risk factor for acute exacerbation. Sublobar resection showed similar survival rate and lower rate of acute exacerbation than lobectomy, although statistically not significant (26.7% vs. 46.6%, p=0.165)
Conclusion : ILD increased the risk of pulmonary resection for lung cancer. VATS were preventive for acute exacerbation. Adjuvant therapy should be considered after careful weighing of risk and benefit.
첨부파일 : figure.docx
책임저자: Jin Gu Lee
Department of Thoracic and Cardiovascular Surgery, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea
발표자: Kyoung Shik Narm, E-mail : cardiosur@yuhs.ac