초록접수 현황
| 17F-207 | 구연 발표 |
Impact of Sex and Body Weight Mismatch on Mid-term Outcomes After Heart Transplantation
Jung-Hwan Kim, Seung Hyun Lee, Hyun-Chel Joo, Sak Lee, Han-Ki Park, Kyung-Jong Yoo, Byung-Chul Chang, Young-Nam Youn
Department of Cardiovascular Surgery, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea
Purpose : We analyzed the impact of sex mismatch and recipient-to-donor weight ratio on mid-term outcomes after heart transplantation.
Methods : From November 1994 to July 2017, a total of 146 heart transplantation recipients were analyzed. We assessed body weight mismatch by calculating the recipient-to-donor weight ratio: <0.7, 0.7 to 1.3, and >1.3. End-points were all-cause mortality and transplantation-related re-admission rate. Mean follow-up duration was 2.8±3.5 years.
Results : The mean age was 41.2±17.0 years and 47 (32.2%) patients were female. The transplantation from male donor (MD) to male recipient (MR) performed in 63 (43.2%), MD to female recipient (FR) performed in 35 (24.0%), female donor (FD) to MR performed in 32 (21.9%), and FD to FR performed in 12 (8.2%). 14 (9.6%) patients had weight ratio of ≥1.3, 107 (73.3%) had 0.7 to 1.3, and 21 (14.4%) had <0.7. FD to FR showed higher 10-year survival rate compared with MD-MR (100% vs. 67.0±6.9%, p=0.049). However, among survivors from in-hospital death, overall survival rate was similar between the sex-mismatched group (p=0.85). Sex-mismatch was not an independent predictor of overall survival (HR=1.04, 95% CI=0.55-1.99, p=0.90) and transplantation-related re-admission (HR=1.28, 95% CI=0.77-2.14, p=0.34) by multivariate analysis. Also, recipient-to-donor weight ratio was not a predictor of overall survival (HR=1.13, 95% CI=0.34-3.75, p=0.84) and transplantation-related re-admission (HR=1.52, 95% CI=0.64-3.61, p=0.35).
Conclusion : Sex and body weight mismatch cannot predict the mid-term outcomes of heart transplantation, but survival rate showed higher tendency in FD-FR group. Alternative parameters should be used to evaluate the size-mismatch in heart transplantation.
Methods : From November 1994 to July 2017, a total of 146 heart transplantation recipients were analyzed. We assessed body weight mismatch by calculating the recipient-to-donor weight ratio: <0.7, 0.7 to 1.3, and >1.3. End-points were all-cause mortality and transplantation-related re-admission rate. Mean follow-up duration was 2.8±3.5 years.
Results : The mean age was 41.2±17.0 years and 47 (32.2%) patients were female. The transplantation from male donor (MD) to male recipient (MR) performed in 63 (43.2%), MD to female recipient (FR) performed in 35 (24.0%), female donor (FD) to MR performed in 32 (21.9%), and FD to FR performed in 12 (8.2%). 14 (9.6%) patients had weight ratio of ≥1.3, 107 (73.3%) had 0.7 to 1.3, and 21 (14.4%) had <0.7. FD to FR showed higher 10-year survival rate compared with MD-MR (100% vs. 67.0±6.9%, p=0.049). However, among survivors from in-hospital death, overall survival rate was similar between the sex-mismatched group (p=0.85). Sex-mismatch was not an independent predictor of overall survival (HR=1.04, 95% CI=0.55-1.99, p=0.90) and transplantation-related re-admission (HR=1.28, 95% CI=0.77-2.14, p=0.34) by multivariate analysis. Also, recipient-to-donor weight ratio was not a predictor of overall survival (HR=1.13, 95% CI=0.34-3.75, p=0.84) and transplantation-related re-admission (HR=1.52, 95% CI=0.64-3.61, p=0.35).
Conclusion : Sex and body weight mismatch cannot predict the mid-term outcomes of heart transplantation, but survival rate showed higher tendency in FD-FR group. Alternative parameters should be used to evaluate the size-mismatch in heart transplantation.
책임저자: Young-Nam Youn
Department of Cardiovascular Surgery, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea
발표자: Jung-Hwan Kim, E-mail : jhkim0907@yuhs.ac