초록접수 현황
| 17F-009 | English competition forum |
Prognosis of younger Patients in Non-small Cell Lung Cancer
Sira Laohathai, Hyo Jun Jang, Yong Won Sung, Kwhanmien Kim, Sanghoon Jheon, Sukki Cho
Department of Thoracic and Cardiovascular Surgery, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Gyeonggi-do, Republic of Korea
Purpose : This study is to compare clinicopathological characteristics, treatment modalities, and prognosis of non-small cell lung cancer (NSCLC) patients between <50 years and >50 years of age at surgery.
Methods : Retrospective review of 2,618 patients with NSCLC who underwent curative intent surgical resection from 2003 to 2015 was obtained from prospectively collected lung cancer database. There were 274 patients (10%) of <50 years old at time of surgery and 2,344 of >50 years. Data regarding demographics, presenting symptoms, histology, tumor staging, treatment modalities (neo, surgical extent, adjuvant therapy), and recurrence, survival were evaluated.
Results : More female, never smoker, adenocarcinoma were found significantly in younger patients. There was no significant difference in presence of symptoms, surgical extents, mutational analysis (EGFR, KRAS), adjuvant therapy and radiotherapy. The pathologic staging was 61% and 59% in stage I, 14% and 19% in stage II, 16% and 18% in stage III, and 8% and 4% in stage IV, respectively. Young patients had a better both 10-year overall survival (OS) and recurrence-free survival (RFS) than those of older patients (76% vs 48.6%; P<0.001, 74% vs 65.8%; P=0.022). In subgroup analysis of each staging, OS and RFS were statistically better in younger patients only in stage I (P<0.001).
Conclusion : The younger patients (<50 years of age at surgery) were more female, never smoker, and adenocarcinoma. Even though there was no difference in treatment modalities, younger patients had significantly better prognosis in pathologic stage I NSCLC.
Methods : Retrospective review of 2,618 patients with NSCLC who underwent curative intent surgical resection from 2003 to 2015 was obtained from prospectively collected lung cancer database. There were 274 patients (10%) of <50 years old at time of surgery and 2,344 of >50 years. Data regarding demographics, presenting symptoms, histology, tumor staging, treatment modalities (neo, surgical extent, adjuvant therapy), and recurrence, survival were evaluated.
Results : More female, never smoker, adenocarcinoma were found significantly in younger patients. There was no significant difference in presence of symptoms, surgical extents, mutational analysis (EGFR, KRAS), adjuvant therapy and radiotherapy. The pathologic staging was 61% and 59% in stage I, 14% and 19% in stage II, 16% and 18% in stage III, and 8% and 4% in stage IV, respectively. Young patients had a better both 10-year overall survival (OS) and recurrence-free survival (RFS) than those of older patients (76% vs 48.6%; P<0.001, 74% vs 65.8%; P=0.022). In subgroup analysis of each staging, OS and RFS were statistically better in younger patients only in stage I (P<0.001).
Conclusion : The younger patients (<50 years of age at surgery) were more female, never smoker, and adenocarcinoma. Even though there was no difference in treatment modalities, younger patients had significantly better prognosis in pathologic stage I NSCLC.
첨부파일 : ppt1.pptx
책임저자: Sukki Cho
Department of Thoracic and Cardiovascular Surgery, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Gyeonggi-do, Republic of Korea
발표자: Sira Laohathai, E-mail : sira_l@hotmail.com