초록접수 현황
| 17F-061 | 구연 미채택시 포럼 발표 |
Sublobar Resection for Clinical Stage 1A Lung Adenocarcinoma with Ground-glass Opacity.
Jae Hyun Jeon, Da Na Moon, Hee Chul Yang, Moon Soo Kim, Jong Mog Lee
Center for Lung Cancer, National Cancer Center, Gyeonggi-do, Republic of Korea
Purpose : Sublobar resection may benefit patients with lung adenocarcinoma presenting as ground-glass opacity nodules (GGNs). The aim of this study was to compare clinical outcomes of patients who have undergone sublobar resection or lobectomy for clinical stage 1A lung adenocarcinoma with ground-glass opacity.
Methods : We conducted a retrospective study of 278 patients who had undergone a complete resection for clinical N0 lung adenocarcinoma ≦ 2 cm with ground glass opacity on chest CT. We assigned them to three groups according to the size of solid part: group A (0 mm ≦ solid part ≦ 5 mm, n = 134), group B (5 mm < solid part ≦ 10 mm, n = 76) and group C (10 mm < solid part ≦ 20 mm, n = 67), and postoperative survival and recurrence were analysed.
Results : In group A and B, there was no significant difference in freedom from recurrence (FFR) between sublobar resection and lobectomy (all p > 0.05). In group C, recurrence rates were higher in patients after sublobar resection than those after standard lobectomy (p = 0.024). The 5-year FFR rate was 64.9% for patients after sublobar resection and 87.3% for patients after standard lobectomy. Among group C patients, multivariate modeling incorporating significant univariate predictors of recurrence revealed that sublobar resection was associated with postoperative recurrence (hazard ratio 6.379, p = 0.019).
Conclusion : Solid part larger than 10 mm may be useful indicator for identifying patients with GGN type clinical N0 lung adenocarcinoma in whom sublobar resection should not be considered.
Methods : We conducted a retrospective study of 278 patients who had undergone a complete resection for clinical N0 lung adenocarcinoma ≦ 2 cm with ground glass opacity on chest CT. We assigned them to three groups according to the size of solid part: group A (0 mm ≦ solid part ≦ 5 mm, n = 134), group B (5 mm < solid part ≦ 10 mm, n = 76) and group C (10 mm < solid part ≦ 20 mm, n = 67), and postoperative survival and recurrence were analysed.
Results : In group A and B, there was no significant difference in freedom from recurrence (FFR) between sublobar resection and lobectomy (all p > 0.05). In group C, recurrence rates were higher in patients after sublobar resection than those after standard lobectomy (p = 0.024). The 5-year FFR rate was 64.9% for patients after sublobar resection and 87.3% for patients after standard lobectomy. Among group C patients, multivariate modeling incorporating significant univariate predictors of recurrence revealed that sublobar resection was associated with postoperative recurrence (hazard ratio 6.379, p = 0.019).
Conclusion : Solid part larger than 10 mm may be useful indicator for identifying patients with GGN type clinical N0 lung adenocarcinoma in whom sublobar resection should not be considered.
책임저자: Jae Hyun Jeon
Center for Lung Cancer, National Cancer Center, Gyeonggi-do, Republic of Korea
발표자: Jae Hyun Jeon, E-mail : jhjeon@ncc.re.kr