초록접수 현황
| 17F-063 | 구연 발표 |
Lymph Node Involvement and Survival of Pathologic Predominant Subtype in Clinical Stage I Invasive Adenocarcinoma using Forthcoming 8th Staging System
Chi Hoon Bae, Tae Hong Yoon, Ki Sung Park
Department of Thoracic and Cardiovascular Surgery, Daegu Catholic University Medical Center, Daegu Catholic University College of Medicine, Daegu, Republic of Korea
Purpose : The goal of this study was to identify pathologic nodal evaluation and survival for patients with surgically resected pathologic predominant subtype in clinical stage I adenocarcinoma.
Methods : We reviewed curative resected clinical stage I adenocarcinoma using forthcoming AJCC 8th cancer staging. The histologic subtypes of all patients were classified according to the IALSC/ATS/ERS classification;lepidic(Lep), acinar(Aci), paillary(Pap) and solid(Sol) predominant. Clinicopathologic variables including visceral pleural invasion(VPI), lymphovascular invasion(LVI), SUVmax in PET-CT, pathologic tumor size, and nodal involvement were evaluated. Survival analysis was estimated using the Kaplan-Meier method.
Results : The number of patients was 98, including 42 males and 56 females. The median follow up period was 44.2 months. Lymph node(pN1 and pN2) involvement was found in 16.3%(16/98). The frequency of nodal involvement in Pap and Sol had higher proportion than other subtypes significantly(p=0.000). The larger tumor and higher SUVmax in PET was significant in nodal involvement(p=0.01, 0.001). In multivariate analysis, SUVmax and LVI each was an independent factor(OR=1.5, 7.4, CI=95). The overall survival for patients with pLN was significantly lower than that without pLN(p=0.002). The median survival times for pLN+ and pLN- were 37.8 and 133.9 months, respectively.
Conclusion : Adenocarcinoma subtypes had a relationship with nodal involvement for patients with clinical stage I. The SUVmax in PET-CT may hint to determine potential nodal status with preoperative staging methods for long term survival.
Methods : We reviewed curative resected clinical stage I adenocarcinoma using forthcoming AJCC 8th cancer staging. The histologic subtypes of all patients were classified according to the IALSC/ATS/ERS classification;lepidic(Lep), acinar(Aci), paillary(Pap) and solid(Sol) predominant. Clinicopathologic variables including visceral pleural invasion(VPI), lymphovascular invasion(LVI), SUVmax in PET-CT, pathologic tumor size, and nodal involvement were evaluated. Survival analysis was estimated using the Kaplan-Meier method.
Results : The number of patients was 98, including 42 males and 56 females. The median follow up period was 44.2 months. Lymph node(pN1 and pN2) involvement was found in 16.3%(16/98). The frequency of nodal involvement in Pap and Sol had higher proportion than other subtypes significantly(p=0.000). The larger tumor and higher SUVmax in PET was significant in nodal involvement(p=0.01, 0.001). In multivariate analysis, SUVmax and LVI each was an independent factor(OR=1.5, 7.4, CI=95). The overall survival for patients with pLN was significantly lower than that without pLN(p=0.002). The median survival times for pLN+ and pLN- were 37.8 and 133.9 months, respectively.
Conclusion : Adenocarcinoma subtypes had a relationship with nodal involvement for patients with clinical stage I. The SUVmax in PET-CT may hint to determine potential nodal status with preoperative staging methods for long term survival.
책임저자: Ki Sung Park
Department of Thoracic and Cardiovascular Surgery, Daegu Catholic University Medical Center, Daegu Catholic University College of Medicine, Daegu, Republic of Korea
발표자: Ki Sung Park, E-mail : kspark69@cu.ac.kr