초록접수 현황
| 17F-106 | 구연 미채택시 포럼 발표 |
Recent Outcomes of Surgical Resection followed by Postoperative Adjuvant Therapy for Non-small Cell Lung Cancer with N2 Disease
Jin San Bok, Dong Kwan Kim, Hyeong Ryul Kim, Yong-Hee Kim, Seung-il Park, Se-Hoon Choi
Department of Thoracic and Cardiovascular Surgery, Asan Medical Center, Ulsan University College of Medicine, Seoul, Republic of Korea
Purpose : Pathologic N2 (pN2) non-small cell lung cancer (NSCLC) have shown poor prognosis, about 30% of 5 year survival rate. However recent advance in diagnostic tools, minimal invasive surgery, chemotherapy, and radiotherapy may improve the prognosis of pN2 disease. In this study, we evaluate the outcomes of surgical resection followed by postoperative adjuvant therapy for NSCLC with pN2 disease.
Methods : The patients with pN2 disease underwent surgical resection followed by adjuvant treatment at single institute. A retrospective medical record review was performed.
Results : From 2004 to 2014, total 680 patients underwent surgical resection for NSCLC with pN2. Among them, 155 patients (22.8%) received adjuvant chemotherapy, 125 patients (18.4%) received adjuvant radiotherapy and 295 patients (43.4%) received adjuvant chemoradiotherapy. The mean age was 60.9 ± 10 years and 446 patients were men (65.6%). Lobectomy was performed in 537 patients (79%), bilobectomy in 56 (8.2%), pneumonectomy in 51 (7.5%). Complete resection was accomplished in 607 patients (89.3%). Extranodal invasion was found in 247 patients (36.3%). Local recurrence occurred in 63 patients (9.3%), distant recurrence in 255 (37.5%). With a mean follow-up of 35 ± 30.1 months, median overall survival (OS) and recurrence free survival (RFS) were 65 ± 5.1 months and 23.3 ± 2.1 months, respectively. 5-year OS rate and RFS rate were 51.8% and 34.5 %, respectively.
Conclusion : In this study, surgical resection followed by postoperative adjuvant therapy showed better outcomes than previously reported. Complete surgical resection and postoperative adjuvant therapy may be important for prognosis.
Methods : The patients with pN2 disease underwent surgical resection followed by adjuvant treatment at single institute. A retrospective medical record review was performed.
Results : From 2004 to 2014, total 680 patients underwent surgical resection for NSCLC with pN2. Among them, 155 patients (22.8%) received adjuvant chemotherapy, 125 patients (18.4%) received adjuvant radiotherapy and 295 patients (43.4%) received adjuvant chemoradiotherapy. The mean age was 60.9 ± 10 years and 446 patients were men (65.6%). Lobectomy was performed in 537 patients (79%), bilobectomy in 56 (8.2%), pneumonectomy in 51 (7.5%). Complete resection was accomplished in 607 patients (89.3%). Extranodal invasion was found in 247 patients (36.3%). Local recurrence occurred in 63 patients (9.3%), distant recurrence in 255 (37.5%). With a mean follow-up of 35 ± 30.1 months, median overall survival (OS) and recurrence free survival (RFS) were 65 ± 5.1 months and 23.3 ± 2.1 months, respectively. 5-year OS rate and RFS rate were 51.8% and 34.5 %, respectively.
Conclusion : In this study, surgical resection followed by postoperative adjuvant therapy showed better outcomes than previously reported. Complete surgical resection and postoperative adjuvant therapy may be important for prognosis.
책임저자: Se-Hoon Choi
Department of Thoracic and Cardiovascular Surgery, Asan Medical Center, Ulsan University College of Medicine, Seoul, Republic of Korea
발표자: Jin San Bok, E-mail : bjssaingk@naver.com