초록접수 현황
| 17F-107 | 구연 미채택시 포럼 발표 |
Limited Resection Versus Lobectomy in T1AN0M0 Lung Cancer: Population Based, Propensity Score Matched Study
Jae Kil Park, Young Kyu Moon, Kyung Soo Kim, Hyung Joo Park, Sook Whan Sung, Seok Whan Moon, Mi Hyoung Moon
Department of Thoracic and Cardiovascular Surgery, Seoul St. Mary’s Hospital, The Catholic University College of Medicine, Seoul, Republic of Korea
Purpose : Recently, interests in lesser resection are increasing for treatment of especially early lung cancer. There are many issues about limited resections regarding tumor size, including indications, advantages, oncologic efficacy and reliability. The purpose of this study is to evaluate the overall (OS) and lung cancer specific(LSS) survival regarding wedge resection, segmentectomy, and lobectomy in primary, stage I lung cancer.
Methods : Patients were selected from the Surveillance, Epidemiology, and End Results (SEER) program, which is a population-based cancer registry sponsored by the National Cancer Institutes since 1972. We selected all patients with histologically confirmed T1N0 primary lung cancer, diagnosed between 2010 and 201, who underwent surgery and actively followed up. We excluded patients who received any type of neo or adjuvant therapy, who were identified from autopsy or death. We used a propensity score (PS) analysis to minimize potential bias caused by nonrandom assignment of patients to each treatment.
Results : Total 13754 patients received either segmentectomy or lobectomy in T1aN0 primary lung cancer. After PS matching, segmentectomy group showed lower OS (p = 0.000) but comparable LSS (p =0.137) compared to the lobectomy group. Multivariate Cox PH showed also either segmentectomy or lobectomy did not increase the risk of LSS. For wedge resection in T1aN0 patients, however, OS (p =0.000) and LSS (p=0.000) were lower than lobectomy in matched population.
Conclusion : For Segmentectomy and lobectomy may lead to equivalent lung cancer specific survival rates among patients with T1aN0M0 primary lung cancer patients. Wedge resections, however, should be cautiously done for highly selected patients.
Methods : Patients were selected from the Surveillance, Epidemiology, and End Results (SEER) program, which is a population-based cancer registry sponsored by the National Cancer Institutes since 1972. We selected all patients with histologically confirmed T1N0 primary lung cancer, diagnosed between 2010 and 201, who underwent surgery and actively followed up. We excluded patients who received any type of neo or adjuvant therapy, who were identified from autopsy or death. We used a propensity score (PS) analysis to minimize potential bias caused by nonrandom assignment of patients to each treatment.
Results : Total 13754 patients received either segmentectomy or lobectomy in T1aN0 primary lung cancer. After PS matching, segmentectomy group showed lower OS (p = 0.000) but comparable LSS (p =0.137) compared to the lobectomy group. Multivariate Cox PH showed also either segmentectomy or lobectomy did not increase the risk of LSS. For wedge resection in T1aN0 patients, however, OS (p =0.000) and LSS (p=0.000) were lower than lobectomy in matched population.
Conclusion : For Segmentectomy and lobectomy may lead to equivalent lung cancer specific survival rates among patients with T1aN0M0 primary lung cancer patients. Wedge resections, however, should be cautiously done for highly selected patients.
첨부파일 : Figure.zip
책임저자: Mi Hyoung Moon
Department of Thoracic and Cardiovascular Surgery, Seoul St. Mary’s Hospital, The Catholic University College of Medicine, Seoul, Republic of Korea
발표자: Mi Hyoung Moon, E-mail : sophiamoon@hanmail.net