초록접수 현황
| 17F-108 | 구연 미채택시 포럼 발표 |
Different Modalities Affecting Survival in Stage IIB (T1-2, N0-1) Esophageal Squamous Cell Carcinoma, Propensity Score Matched Analysis using Population Based Study
Jae Kil Park, Young Kyu Moon, Kyung Soo Kim, Hyung Joo Park, Sook Whan Sung, Seok Whan Moon, Mi Hyoung Moon
Department of Thoracic and Cardiovascular Surgery, Seoul St. Mary’s Hospital, The Catholic University College of Medicine, Seoul, Republic of Korea
Purpose : The purpose of this study is to elucidate the effect of different treatment modalities , esophagectomy only versus combined modalities, versus nonsurgical modalities on the cancer specific survival (CSS) in resectable stage IIB (T1-2, N0-1) squamous esophageal carcinoma (SCC) in the real world practice.
Methods : Patients were selected from the Surveillance, Epidemiology, and End Results (SEER) program, which is a population-based cancer registry sponsored by the National Cancer Institutes since 1972. Patients with primary SCC in the mid to lower esophagus were selected, and primary outcome was CSS and overall survival (OS). Five distinctive treatment groups were defined : esophagectomy only, esophagectomy and chemotherapy ± radiation, nonsurgical single treatment (either radiation or chemotherapy), chemoradiation, and no treatment. To balance the patients for surgical assignment, we used propensity score matched (PSM) survival analysis.
Results : After PSM, multivariate Cox PH analysis demonstrated that treatment modality, marital status, and T and N stage were significant for cancer specific survival. Best survival showed esophagectomy plus chemoradiation (median survival 67 months), followed by esophagectomy (median survival 66 months), and chemoradiation group (median survival 37 months). Either chemotherapy only or radiation only method showed poor survival.
Conclusion : In T1-2, N0-1 squamous esophageal carcinoma, esophagectomy alone seemed comparable survival to the esophagectomy plus chemoradiation therapy.
Methods : Patients were selected from the Surveillance, Epidemiology, and End Results (SEER) program, which is a population-based cancer registry sponsored by the National Cancer Institutes since 1972. Patients with primary SCC in the mid to lower esophagus were selected, and primary outcome was CSS and overall survival (OS). Five distinctive treatment groups were defined : esophagectomy only, esophagectomy and chemotherapy ± radiation, nonsurgical single treatment (either radiation or chemotherapy), chemoradiation, and no treatment. To balance the patients for surgical assignment, we used propensity score matched (PSM) survival analysis.
Results : After PSM, multivariate Cox PH analysis demonstrated that treatment modality, marital status, and T and N stage were significant for cancer specific survival. Best survival showed esophagectomy plus chemoradiation (median survival 67 months), followed by esophagectomy (median survival 66 months), and chemoradiation group (median survival 37 months). Either chemotherapy only or radiation only method showed poor survival.
Conclusion : In T1-2, N0-1 squamous esophageal carcinoma, esophagectomy alone seemed comparable survival to the esophagectomy plus chemoradiation therapy.
첨부파일 : Figure.zip
책임저자: Mi Hyoung Moon
Department of Thoracic and Cardiovascular Surgery, Seoul St. Mary’s Hospital, The Catholic University College of Medicine, Seoul, Republic of Korea
발표자: Mi Hyoung Moon, E-mail : sophiamoon@hanmail.net