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17F-125 구연 미채택시 포럼 발표

Detailed Prognostic Impact of Lymphovascular Invasion in Resected Lung Adenocarcinoma
Jung Hoon Yi, Pil Jo Choi, Sang Seok Jeong, Joo Hyun Cho
Department of Thoracic and Cardiovascular Surgery, Dong-A University Hospital, Dong-A University College of Medicine, Busan, Republic of Korea

Purpose : Lymphovascular invasion (LVI) is considered a fundamental step toward locoregional and systemic disease spread as well as a prognostic factor in non-small cell carcinoma. We focused LVI on a range having influence on the prognosis of survival and recurrence pattern in adenocarcinoma.

Methods : Between January 2004 and July 2015, a total of 233 consecutive patients who underwent complete resection with systemic lymph node dissection at our hospital with pathologic stage T1-4N0-2M0 adenocarcinoma were identified. Cox proportional hazard model was used to assess the independent prognostic factor of survival and recurrence. Kaplan-Meier methods were performed to estimate overall survival (OS) and recurrence-free survival (RFS) by stage and tumor size.

Results : Median follow-up duration was 56.3 months, and 64 patients (27.5%) had LVI. Presence of LVI was associated with maximal standardized uptake value, tumor size, nodal metastasis, visceral pleural invasion, and predominant subtype of adenocarcinoma. Multivariate analysis revealed LVI was the independent prognostic factor of both OS (hazard ratio [HR] = 2.038, p = 0.019) and RFS (HR 1.788, p = 0.045). In the analysis according to tumor size, the incidence of LVI increased with tumor size (p = 0.023). Moreover, survival differences were statistically valid only when the tumor size was less than 3 cm, and when the disease was stageⅠ. There were 45 locoregional recurrences and 54 distant metastases, and LVI was found to be a predictor independent of the recurrence pattern by multivariate analysis.

Conclusion : LVI is a size-specific, stage-specific prognostic factor of survival and recurrence, independent of the recurrence pattern.


책임저자: Pil Jo Choi
Department of Thoracic and Cardiovascular Surgery, Dong-A University Hospital, Dong-A University College of Medicine, Busan, Republic of Korea
발표자: Jung Hoon Yi, E-mail : yjh051@daum.net

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