초록접수 현황
| 17F-132 | 구연 발표 |
Alternatively Activated Macrophage Correlate With Multi-drug Resistant Tuberculosis
Hyun Jin Cho¹, Jhingook Kim², Yun-Ji Lim³, Chang-Hwa Song³, Min-Woong Kang¹
¹Department of Thoracic and Cardiovascular Surgery, Chungnam National University Hospital, Chungnam National University College of Medicine, Daejeon, Republic of Korea., ²Department of Thoracic and Cardiovascular Surgery, Samsung Biomedical Research Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea., ³Department of Microbiology, Chungnam National University Hospital, Chungnam National University College of Medicine, Daejeon, Republic of Korea
Purpose : Macrophages are immune cell in charge of a first-line defense to mycobacterium infection and play a key role on the formation of the tuberculous granuloma. Alternatively activated macrophages (M2) play an important role in tissue repair and persistent infection through the immune escape of tumors and pathogens. Immune escape of pathogens from drug and host immunity may be one of the main causes for treatment failure or relapsed TB. In this study, M1 and M2 polarization rate in surgically resected lung specimen of MDR-TB and drug-sensitive TB (DS-TB) patients were investigated.
Methods : We collected patients who underwent surgical treatment for pulmonary TB at two centers from January 1998 through December 2014. One hundred twenty-five patients enrolled in this study. Immunohistochemistry stain and imaging analysis for iNOS and Arginase 1, surface marker of polarized macrophage, from the tissue specimens were carried out by two researchers.
Results : Mean age was 38.5 years, and 72 patients were male (57.6%). DR-TB group was 98 patients and DS-TB group was 27 patients (21.6%). Younger age (odds 0.903, 95% CI 0.854-0.955) and M2 polarized macrophage (odds 1.042, 95% CI 1.017-1.068) were significantly correlated with DR-TB. There was no correlation between M1 polarization and M2 polarization (R2 (L) = 0.008). The M2 polarization was not correlated with in DR-TB high M1 group, but was significantly correlated with DR-TB in low M1 group.
Conclusion : M2 macrophage was significantly correlated with MDR-TB. Further investigation needed to determine the role of macrophage polarization in the treatment of MDR-TB.
Methods : We collected patients who underwent surgical treatment for pulmonary TB at two centers from January 1998 through December 2014. One hundred twenty-five patients enrolled in this study. Immunohistochemistry stain and imaging analysis for iNOS and Arginase 1, surface marker of polarized macrophage, from the tissue specimens were carried out by two researchers.
Results : Mean age was 38.5 years, and 72 patients were male (57.6%). DR-TB group was 98 patients and DS-TB group was 27 patients (21.6%). Younger age (odds 0.903, 95% CI 0.854-0.955) and M2 polarized macrophage (odds 1.042, 95% CI 1.017-1.068) were significantly correlated with DR-TB. There was no correlation between M1 polarization and M2 polarization (R2 (L) = 0.008). The M2 polarization was not correlated with in DR-TB high M1 group, but was significantly correlated with DR-TB in low M1 group.
Conclusion : M2 macrophage was significantly correlated with MDR-TB. Further investigation needed to determine the role of macrophage polarization in the treatment of MDR-TB.
책임저자: Min-Woong Kang
Department of Thoracic and Cardiovascular Surgery, Chungnam National University Hospital, Chungnam National University College of Medicine, Daejeon, Republic of Korea
발표자: Hyun Jin Cho, E-mail : irainy79@naver.com