초록접수 현황
| 17F-064 | 구연 발표 |
Long-term Survival and Prognosis of Surgically Treated Thymic Carcinoma: A Multi-institutional Study of 239 Cases
Yeong Jeong Jeon¹, Yong Soo Choi¹, Jae Jun Jung¹, Sumin Shin¹, Jong Ho Cho¹, Hong Kwan Kim¹, Jhingook Kim¹, Jae Il Zo¹, Young Mog Shim¹, Samina Park², Kwan Yong Hyun², Yoohwa Hwang², Hyun Joo Lee², In Kyu Park², Chang Hyun Kang², Young Tae Kim², Geun Dong Lee³, Hyeong Ryul Kim³, Su Kyung Hwang³, Se Hoon Choi³, Yong-Hee Kim³, Dong Kwan Kim³, Seung-Il Park³, Chang Young Lee⁴, Jin Gu Lee⁴, Dae Joon Kim⁴, Hyo Chae Paik⁴, Kyoung Young Chung⁴
¹Department of Thoracic and Cardiovascular Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea., ²Department of Thoracic and Cardiovascular Surgery, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea., ³Department of Thoracic and Cardiovascular Surgery, Asan Medical Center, Ulsan University College of Medicine, Seoul, Republic of Korea., ⁴Department of Thoracic and Cardiovascular Surgery, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea
Purpose : Thymic carcinoma is a rare and highly malignant tumor. The aim of this study was to evaluate the long-term outcome after surgical treatment and the prognostic factors of thymic carcinoma using a multi-institutional database in Korea.
Methods : From January 2000 to December 2013, a total of 239 patients with surgically treated thymic carcinomas collected from 4 Korean institutions were enrolled. Survival analysis was performed using Kaplan-Meier curves and log rank tests. Univariate analysis was performed using Cox regression models
Results : Of the 239 patients, complete resection was achieved in 192 (80%) patients. Median follow-up duration was 47.3 months. The 5- and 10-year overall survival (OS) rates were 76.4±3.2% and 48.4±6.0%, respectively (Figure 1). The 5- and 10-year disease-free survival (DFS) rates were 59.3±4.1% and 56.8±4.3%, respectively (Figure 2). In the univariate analysis, age (≥65 years) and advanced Masaoka-Koga stage had negative impacts on OS and DFS. Tumor size of 7 cm or greater on initial chest computed tomography (CT) or pathology was a significant prognostic factor of OS, and tended to be associated with an increased risk of the recurrence in the univariate analysis (Table 1).
Conclusion : Tumor size of 7 cm or greater had worse prognosis of surgically treated thymic carcinomas. Further, the age and pathologic Masaoka-Koga stage were significantly associated with both OS and DFS.
Methods : From January 2000 to December 2013, a total of 239 patients with surgically treated thymic carcinomas collected from 4 Korean institutions were enrolled. Survival analysis was performed using Kaplan-Meier curves and log rank tests. Univariate analysis was performed using Cox regression models
Results : Of the 239 patients, complete resection was achieved in 192 (80%) patients. Median follow-up duration was 47.3 months. The 5- and 10-year overall survival (OS) rates were 76.4±3.2% and 48.4±6.0%, respectively (Figure 1). The 5- and 10-year disease-free survival (DFS) rates were 59.3±4.1% and 56.8±4.3%, respectively (Figure 2). In the univariate analysis, age (≥65 years) and advanced Masaoka-Koga stage had negative impacts on OS and DFS. Tumor size of 7 cm or greater on initial chest computed tomography (CT) or pathology was a significant prognostic factor of OS, and tended to be associated with an increased risk of the recurrence in the univariate analysis (Table 1).
Conclusion : Tumor size of 7 cm or greater had worse prognosis of surgically treated thymic carcinomas. Further, the age and pathologic Masaoka-Koga stage were significantly associated with both OS and DFS.
첨부파일 : Figure & table.docx
책임저자: Yong Soo Choi
Department of Thoracic and Cardiovascular Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
발표자: Jae Jun Jung, E-mail : adonismind@naver.com