초록접수 현황
| 17F-084 | 구연 미채택시 포럼 발표 |
Dramatic Size Reduction of Thymic Neoplasm after Neoadjuvant Treatment could Not Improve R0 Resection Rate and Survival.
Jee Won Suh, Jin Gu Lee, Go Eun Byun, Kyoung Sik Narm, Chang Young Lee, Seong Yong Park, Dae Joon Kim, Kyoung Young Chung
Department of Thoracic and Cardiovascular Surgery, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea
Purpose : In locally advanced thymoma and thymic carcinoma, complete resection is important in terms of prognosis. The purpose of this study was to evaluate the effect of neoadjuvant therapy in locally advanced thymic neoplasm.
Methods : From January 1, 2000 to December 31, 2013, patients who underwent surgical resection for M-K stage III-IV thymic neoplasm were enrolled. A total of 90 patients were enrolled. Initial treatment of 71 patients was surgery, and neoadjuvant therapy was followed by surgery in 19 patients. In neoadjuvant group, tumor volume and hilar invasion area were measured before and after neoadjuvant treatment by Synapse 3D (Fuji Film).
Results : Mean age was 53.89± 12.66 yr in initial surgery group and 47.42±11.95 in neoadjuvant group (p=0.049). In neoadjuvant group, tumor volume and area of hilar invasion were significantly decreased from 206.08±132.32 to 81.25±71.24 (p=0.001) and 41.14±15.21 to 24.53±12.86 (p=0.000)(Fig 1). Phrenic nerve sacrifice was more common in neoadjuvant group (15 (21.1%) vs 10 (52.6%), p= 0.010). Number of adjacent mediastinal structure invasion was larger in neoadjuvant group (1.27±1.09 vs 2.53±1.43, p=0.000). Despite the significant size reduction, neoadjuvant treatment could not show the difference of R0 resection rate compared with initial surgery group (OR 1.141, p=0.847). Even more, 5 year disease free survival was pooper in neoadjuvant group (26.6 vs. 53.5%, p=0.040) and 5 year overall survival was not different between two groups (63.2% vs. 72.4%, p=0.189).
Conclusion : Neoadjuvant treatment could significantly reduce tumor volumes, however it could not effect on R0 resection rate and survival in thymic neoplasm.
Methods : From January 1, 2000 to December 31, 2013, patients who underwent surgical resection for M-K stage III-IV thymic neoplasm were enrolled. A total of 90 patients were enrolled. Initial treatment of 71 patients was surgery, and neoadjuvant therapy was followed by surgery in 19 patients. In neoadjuvant group, tumor volume and hilar invasion area were measured before and after neoadjuvant treatment by Synapse 3D (Fuji Film).
Results : Mean age was 53.89± 12.66 yr in initial surgery group and 47.42±11.95 in neoadjuvant group (p=0.049). In neoadjuvant group, tumor volume and area of hilar invasion were significantly decreased from 206.08±132.32 to 81.25±71.24 (p=0.001) and 41.14±15.21 to 24.53±12.86 (p=0.000)(Fig 1). Phrenic nerve sacrifice was more common in neoadjuvant group (15 (21.1%) vs 10 (52.6%), p= 0.010). Number of adjacent mediastinal structure invasion was larger in neoadjuvant group (1.27±1.09 vs 2.53±1.43, p=0.000). Despite the significant size reduction, neoadjuvant treatment could not show the difference of R0 resection rate compared with initial surgery group (OR 1.141, p=0.847). Even more, 5 year disease free survival was pooper in neoadjuvant group (26.6 vs. 53.5%, p=0.040) and 5 year overall survival was not different between two groups (63.2% vs. 72.4%, p=0.189).
Conclusion : Neoadjuvant treatment could significantly reduce tumor volumes, however it could not effect on R0 resection rate and survival in thymic neoplasm.
첨부파일 : Figure 1 thymoma 초록.docx
책임저자: Kyoung Young Chung
Department of Thoracic and Cardiovascular Surgery, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea
발표자: Jee Won Suh, E-mail : suh_1225@yuhs.ac