초록접수 현황
| 17F-098 | 구연 발표 |
Clinical Outcomes of Pulmonary Resection for Non-small Cell Lung Cancer with Pleural Seeding Incidentally Detected during Surgery
Jae Kwang Yun, Min Kyun Kang, Hyeong Ryul Kim, Byung Kwon Chong, Han Pil Lee, Geun Dong Lee, Se Hoon Choi, Yong-Hee Kim, Dong Kwan Kim, Park Seung-Il
Department of Thoracic and Cardiovascular Surgery, Asan Medical Center, Ulsan University College of Medicine, Seoul, Republic of Korea
Purpose : The aim of this study is to evaluate the clinical outcomes of surgical resection in patients with NSCLC with pleural seeding incidentally detected during surgery.
Methods : We evaluated a retrospective data of 126 patients(median, 61 years, range, 29-79 years; 71 males) who underwent surgery for NSCLC with pleural seeding incidentally detected during surgery from January 2000 to December 2016. Exploration with pleural biopsy was performed in 71 cases of these patients(exploration-only group) and pulmonary resection, including for the main tumor, was performed in 55 cases(resection group;sublobar resection in 25, lobectomy in 27, pneumonectomy in 3 patients).
Results : Baseline characteristics including age, sex, clinical T/N status were not significantly different between the two groups. Adenocarcinoma was predominant in both groups(90.1 and 92.7%). A tyrosine kinase inhibitor(TKI) was used postoperatively in 30 patients of the exploration-only group and 25 patients of the resection group. There was no significant difference in survival rates between TKI-used and not-used patients in both groups(P=0.202 and 0.55). Among all patients, epidermal growth factor receptor(EGFR) mutation was detected in 88(69.8%)patients. There was no significant difference in survival rates between EGFR mutation positive and negative patients(P=0.922). There were no postoperative deaths in both groups. The overall 5-year survival rates were 25.4±5.6% in the exploration-only group and 40.0±7.4% in the resection group. There was significant difference in survival rates between groups(P=0.009). In multivariate analysis, surgical resection was the only significant prognostic factor(P=0.005).
Conclusion : Pulmonary resection including the main tumor may increase survival in patients with NSCLC with pleural seeding incidentally detected during surgery.
Methods : We evaluated a retrospective data of 126 patients(median, 61 years, range, 29-79 years; 71 males) who underwent surgery for NSCLC with pleural seeding incidentally detected during surgery from January 2000 to December 2016. Exploration with pleural biopsy was performed in 71 cases of these patients(exploration-only group) and pulmonary resection, including for the main tumor, was performed in 55 cases(resection group;sublobar resection in 25, lobectomy in 27, pneumonectomy in 3 patients).
Results : Baseline characteristics including age, sex, clinical T/N status were not significantly different between the two groups. Adenocarcinoma was predominant in both groups(90.1 and 92.7%). A tyrosine kinase inhibitor(TKI) was used postoperatively in 30 patients of the exploration-only group and 25 patients of the resection group. There was no significant difference in survival rates between TKI-used and not-used patients in both groups(P=0.202 and 0.55). Among all patients, epidermal growth factor receptor(EGFR) mutation was detected in 88(69.8%)patients. There was no significant difference in survival rates between EGFR mutation positive and negative patients(P=0.922). There were no postoperative deaths in both groups. The overall 5-year survival rates were 25.4±5.6% in the exploration-only group and 40.0±7.4% in the resection group. There was significant difference in survival rates between groups(P=0.009). In multivariate analysis, surgical resection was the only significant prognostic factor(P=0.005).
Conclusion : Pulmonary resection including the main tumor may increase survival in patients with NSCLC with pleural seeding incidentally detected during surgery.
첨부파일 : Fig 1.docx
책임저자: Hyeong Ryul Kim
Department of Thoracic and Cardiovascular Surgery, Asan Medical Center, Ulsan University College of Medicine, Seoul, Republic of Korea
발표자: Jae Kwang Yun, E-mail : janies@nate.com